New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency

ObjectiveTo characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role the evaluation premature (POI).DesignRetrospective cohort study.SettingUniversity-based center for reproductive medicine.Patient(s)A total 145 women, including 48 patients with POI (25 IU/L < follicle-stimulating hormone [FSH] ?40 IU/L), 49 biochemical (bPOI) (10 FSH ?25 IU/L) age-matched control women normal reserve (FSH <10 retrospectively included from hospital affiliated Shandong University between 2017 2019.Intervention(s)Levels INSL3 serum follicular fluid assayed a commercial radioimmunoassay.Main Outcome Measure(s)Level among bPOI POI, association markers, predictive value POI.Result(s)The level continuously declined progress insufficiency. It showed strong negative (?0.655) luteinizing (?0.433), but positively correlated antimüllerian (0.617), inhibin B (0.400), antral follicle count (0.630), testosterone (0.180). Additionally, served as good predictor POI. No statistically significant difference levels was observed women.Conclusion(s)For first time our study has revealed an deficiency indicating that could serve promising theca-cell specific marker Future research on modulating development, steroidogenesis, pathogenesis is warranted. To (POI). Retrospective study. University-based medicine. A 2019. Levels radioimmunoassay. Level The women. For